MONTREAL – Researchers at Montreal's McGill University say a recent study appears to refute the hypothesis that anti-inflammatory drugs could help stop the progression of Alzheimer's disease.
The school tested the effect of the anti-inflammatory drug naproxen on 200 participants who were at risk of developing the disease but were still not showing symptoms.
The study's authors say the two-year clinical trial showed no evidence that taking the common drug, which is sold under Aleve, had any effect on the progression of the disease compared to a placebo.
The school says researchers have known for decades that inflammation accompanies Alzheimer's brain injuries, which led to the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) could help stop or prevent the disease.
But the researchers say subsequent clinical trials point to the conclusion that the drugs do not make a difference, regardless of whether the patients are already experiencing impairment cognitive.
Lead author Dr. John Breitner says the results suggest that researchers will have to look elsewhere in their search for a much needed way to prevent the disease.