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A micro-RNA, a molecule near DNA, involved in autism



A micro-RNA, a molecule near DNA, involved in autism

Source: Sciencesetavenir.fr

11/12/2018 10:03

A team from Emory University and the Chinese Academy of Sciences explored the role of a micro-RNA in the development of autistic spectrum disorders. And he imagined a treatment, effective in mice.

The genetic causes of autism are becoming increasingly common. A study involves a malfunction of a microRNA called MIR-137 in the development of the disease. What is a micro-RNA? It is a small molecule near DNA, but whose function is not to encode proteins that make the cell. Micro-RNAs (also called myRNAs) work to regulate biological processes such as cellular development, differentiation, growth and metabolism. By degrading the messenger RNA (which has a function of "coding" for proteins) or by stopping the synthesis of proteins, they inhibit the expression of different genes.

According to several studies published in recent years (notably an article by Ebrahim Mahmoudi and Murray Cairns, published in Molecular Psychiatry of Nature in 2017), the MIR-137 plays a critical role in the functioning of the brain. In fact, it regulates several hundreds of genes. When it fails, the activity of these genes is impaired, causing cellular dysfunctions that can cause neuropsychiatric disorders, including autism. But the exact mechanics of this phenomenon is little known. It is the fault that came to cover a study published by a team of researchers from the University of Emory and the Chinese Academy of Sciences in Neuroscience of nature …

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