Clinical use against autoimmune diseases, allergies and cancer
"autoimmune diseases and allergies are among the most common emerging diseases around the world and therapies are urgently needed. Here ours discovery be enormously useful. If it is BH4 inhibit, we can inhibit the constant attack mode of these self-aggressive T cells, so do not destroy the healthy tissue or cause chronic inflammation, "he said Shane Cronin, Postdoc at IMBA and first author of the current publication at nature,
Clifford Woolf from Boston Children's Hospital in Harvard e Kai Johnsson. Max Planck Institute of Medical Research, Heidelberg, researchers have developed a new drug called QM385, a BH4 inhibits e immune cells with exaggerated damages "Sundays". The first clinical trials are in offing.
BH4 also for cancer therapy?
BH4 At the same time, it is also an important candidate for future cancer immunotherapies, since activated T cells detect and fight cancer cells. The researchers found that mice BH4 T cells help to attack the tumor. It was also discovered that the appearance of BH4 It can be blocked by kynurenine, a molecule that immune system it can be deactivated in tumors. The gift of BH4 It allows T cells to grow again.
Valuable knowledge of relationships
"The knowledge of new relationships in biology and the onset of diseases is particularly valuable because the applications can be very versatile. Who would think that our immune system controlled by a molecule known by neurobiology and possibly new applications autoimmune diseasesAsthma could even lead to cancer and immunodeficiency! ", Said Shane Cronin,
"If cross-connections of different biological systems in the body can be found, as in this case the nervous system and the immune systemSometimes you can be surprised discoveries do. "In the past, this is about the team around Josef Penninger Using the example of the RANKL signaling pathway, it was possible to link bone metabolism and the hormonal system. Uses of the resulting drug therapy denosumab range from bone loss to a breast cancer pill, currently
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