LONDON (Reuters) – British scientists at the University of Oxford have developed a genetically modified virus that can kill cancer cells. The virus attacks both healthy tumors and cells, known as fibroblasts, which were "deceived" to protect the immune system's cancer. "You can also destroy the existing bone marrow and the skin.
This is the first time that fibroblasts associated with cancer have been subjected to tumors, according to the researchers.
"Even when most cancer cells are killed in cancer, fibroblasts can protect the residual parts of cancer and help them recover and reparticulate again," said Dr. Kerry Fisher of the University of Oxford Department of Oncology, who directed the study . "So far there was no way to kill" Our new vision of targeting fibroblasts at the same time as killing cancer cells is an important step in reducing the suppression of the immune system and giving it the opportunity to initiate the process of natural immunity. "
The virus, called enadenotucirev, is being used in clinical trials to treat cancers that begin in the pancreas, colon, lungs, breasts, ovaries or prostate.
Scientists attach a biological virus to the virus. One end of the protein binds to fibroblasts, while the other binds to T cells, a type of immune cell responsible for killing defective cells. This link caused the death of fibroblasts associated with tumors.
"This innovative viral delivery system aimed at both cancer and the surrounding protective tissue can improve the results in patients whose cancer is resistant to current treatment," said Dr. Nathan Richardson, chair of Molecular and Molecular Medicine at the Medical Research Council (MRC).
The results of the study were published in the Journal of Cancer Research. The researchers examined the treatment with mice and samples of human cancer, testing them in samples of healthy human bone marrow and found that they did not cause any type of toxicity.
If more safety tests are successful, the virus can be tested in cancer patients next year.